Mood herb found to increase lifespan



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December 30, 2007  
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CM NEWS, University of California, Irvine release – The herbal extract of a yellow-flowered mountain plant indigenous to the Arctic regions of Europe and Asia increased the lifespan of fruit fly populations, according to a University of California, Irvine study.

rhodiola-rosea.jpgFlies that ate a diet rich with Rhodiola rosea (hong jing tian in Chinese, ???), an herbal supplement long used for its purported stress-relief effects, lived on an average of 10 percent longer than fly groups that didn’t eat the herb. Study results appear in the online version of Rejuvenation Research.

What is rhodiola rosea? Rhodiola rosea (Golden Root, Roseroot) is a plant in the Crassulaceae family that grows in cold regions of the world. These include much of the Arctic, the mountains of Central Asia, the Rocky Mountains, and mountainous parts of Europe, such as the Alps, Pyrenees, Carpathian Mountains, Scandinavia, Iceland, Great Britain and Ireland.

Rhodiola rosea is effective for improving mood and alleviating depression. Russian research shows that it improves both physical and mental performance, reduces fatigue, and prevents high-altitude sickness. In one study, the Rhodiola rosea group decreased proofreading errors by 88% while the control group increased proofreading errors by 84%. Rhodiola rosea’s effects are attributed to its ability to optimise serotonin and dopamine levels, due to monoamine oxidase inhibition and to its influence on opioid peptides such as beta-endorphins.

Substances like these are referred to as adaptogens. They differ from stimulants, and do not have the same health consequences as nicotine, etc.

In Russia, Rhodiola rosea, also known as golden root, has been used for centuries to cope with the cold Siberian climate and stressful life. It has also been used for centuries in Scandinavia, both by the Vikings and the Sámi. Note that Rhodiola is sometimes inappropriately referred to as “Arctic Root”, which is a trademark product name held by the Swedish Herbal Institute for an extract SHR-5 which contains unique Rhodiola rosea extracts tested in human clinical trials. Publication of a double-blind, placebo controlled clinical trial shows a significant effect for SHR-5 Rhodiola extract in cases of mild-to-moderate depression.

“Although this study does not present clinical evidence that Rhodiola can extend human life, the finding that it does extend the lifespan of a model organism, combined with its known health benefits in humans, make this herb a promising candidate for further anti-aging research,” said Mahtab Jafari, a professor of pharmaceutical sciences and study leader. “Our results reveal that Rhodiola is worthy of continued study, and we are now investigating why this herb works to increase lifespan.”

In their study, the UC Irvine researchers fed adult fruit fly populations diets supplemented at different dose levels with four herbs known for their anti-aging properties. The herbs were mixed into a yeast paste, which adult flies ate for the duration of their lives. Three of the herbs – known by their Chinese names as Lu Duo Wei, Bu Zhong Yi Qi Tang and San Zhi Pian – had no effect on fruit fly longevity, while Rhodiola was found to significantly reduce mortality. On average, Rhodiola increased survival 3.5 days in males and 3.2 days in females.

Rhodiola rosea, also known as the golden root, grows in cold climates at high altitudes and has been used by Scandinavians and Russians for centuries for its anti-stress qualities. The herb is thought to have anti-oxidative properties and has been widely studied.

Soviet researchers have been studying Rhodiola since the 1940s on athletes and cosmonauts, finding that the herb boosts the body’s response to stress. And earlier this year, a Nordic Journal of Psychiatry study on people with mild-to-moderate depression showed that patients taking a Rhodiola extract called SHR-5 reported fewer symptoms of depression than did those who took a placebo.

Jafari said she is evaluating the molecular mechanism of Rhodiola by measuring its impact on energy metabolism, oxidative stress and anti-oxidant defenses in fruit flies. She is also beginning studies in mice and in mouse and human cell cultures. These latter studies should help understand the benefits of Rhodiola seen in human trials.

Jeffrey Felgner, Irvin Bussel, Anthony Hutchili, Behnood Khodayari, Michael Rose and Laurence Mueller of UC Irvine participated in the study. Sun Ten Inc. provided the herbs.

Full story here.